IRCCS Ospedale Policlinico San Martino-IRCCS Italian Cardiovascular Network & Department of Internal Medicine, University of Genova, 16132 Genova, Italy.
Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center, Dallas, TX 75206, USA.
Int J Mol Sci. 2020 Feb 11;21(4):1192. doi: 10.3390/ijms21041192.
Despite important advances in diagnosis and treatment, heart failure (HF) remains a syndrome with substantial morbidity and dismal prognosis. Although implementation and optimization of existing technologies and drugs may lead to better management of HF, new or alternative strategies are desirable. In this regard, basic science is expected to give fundamental inputs, by expanding the knowledge of the pathways underlying HF development and progression, identifying approaches that may improve HF detection and prognostic stratification, and finding novel treatments. Here, we discuss recent basic science insights that encompass major areas of translational research in HF and have high potential clinical impact.
尽管在诊断和治疗方面取得了重要进展，但心力衰竭（HF）仍然是一种发病率高、预后不良的综合征。尽管现有技术和药物的实施和优化可能会导致 HF 得到更好的管理，但仍需要新的或替代的策略。在这方面，基础科学有望通过扩展 HF 发展和进展的潜在途径的知识，确定可能改善 HF 检测和预后分层的方法，并寻找新的治疗方法，为其提供基本的投入。在这里，我们讨论了最近的基础科学见解，这些见解涵盖了 HF 转化研究的主要领域，具有很高的临床应用潜力。
