Wodarz Andreas, Näthke Inke
Department of Stem Cell Biology, DFG Research Center for Molecular Physiology of the Brain (CMPB), University of Göttingen, Justus-von-Liebig-Weg 11, 37077 Göttingen, Germany.
Nat Cell Biol. 2007 Sep;9(9):1016-24. doi: 10.1038/ncb433.
The development of cancer is a multistep process in which the DNA of a single cell accumulates mutations in genes that control essential cellular processes. Loss of cell-cell adhesion and cell polarity is commonly observed in advanced tumours and correlates well with their invasion into adjacent tissues and the formation of metastases. Growing evidence indicates that loss of cell-cell adhesion and cell polarity may also be important in early stages of cancer. The strongest hints in this direction come from studies on tumour suppressor genes in the fruitfly Drosophila melanogaster, which have revealed their importance in the control of apical-basal cell polarity.
癌症的发展是一个多步骤过程，在此过程中单个细胞的DNA在控制基本细胞过程的基因中积累突变。细胞间粘附和细胞极性的丧失在晚期肿瘤中普遍存在，并且与其侵入相邻组织和形成转移密切相关。越来越多的证据表明，细胞间粘附和细胞极性的丧失在癌症早期可能也很重要。这方面最有力的线索来自对果蝇黑腹果蝇肿瘤抑制基因的研究，这些研究揭示了它们在控制顶-基细胞极性中的重要性。
