Luukkaa Heikki, Laitakari Jaakko, Vahlberg Tero, Klemi Pekka, Grénman Reidar
Department of Otorhinolaryngology-Head and Neck Surgery, University of Turku, and Turku University Central Hospital, Finland.
Acta Otolaryngol. 2007 Aug;127(8):869-73. doi: 10.1080/00016480601053099.
In computer-assisted analysis of acinic cell cancer (ACC) morphological characteristics of CD34 immunoreactivity were detected. Bigger vessel size, vessel irregularity, and lower intensity of CD34-positive vessel staining may indicate unfavorable prognosis.
Salivary gland cancer (SGC) is a morphologically diverse group of malignancies, the most common histological types being mucoepidermoid, adenoid cystic and ACC, which has the most favorable prognosis of the three. The aim of this research was to study the applicability of automated image analysis as prognostic criteria in ACC.
In a nationwide study covering SGC patients in Finland during 1991-1996, 34 patients with ACC (15 males, 19 females, aged 19-95 years, mean 55 years) were included. Parameters were measured from CD34-stained samples.
In all, 10 385 vessels were measured, of which 9873 were from specimens from patients who were alive 5 years after treatment (n=32, group I) and 512 were from patients who died of disease (n=2, group II). The following results were found in group II versus group I: mean vessel size 469 microm vs 272 microm (p=0.024); vessel irregularity 28.3 microm vs 22.3 microm (p<0.001); CD34 staining intensity 0.555 microm vs 0.584 microm (p=0.024).
在对腺泡细胞癌（ACC）的计算机辅助分析中，检测到了CD34免疫反应性的形态学特征。较大的血管尺寸、血管不规则性以及CD34阳性血管染色强度较低可能预示预后不良。
唾液腺癌（SGC）是一组形态多样的恶性肿瘤，最常见的组织学类型为黏液表皮样癌、腺样囊性癌和ACC，其中ACC在这三种类型中预后最佳。本研究的目的是探讨自动图像分析作为ACC预后标准的适用性。
在一项覆盖1991 - 1996年芬兰SGC患者的全国性研究中，纳入了34例ACC患者（男性15例，女性19例，年龄19 - 95岁，平均55岁）。从CD34染色样本中测量参数。
共测量了10385条血管，其中9873条来自治疗后存活5年的患者标本（n = 32，第一组），512条来自死于疾病的患者标本（n = 2，第二组）。第二组与第一组相比，得到以下结果：平均血管尺寸469微米对272微米（p = 0.024）；血管不规则性28.3微米对22.3微米（p < 0.001）；CD34染色强度0.555微米对0.584微米（p = 0.024）。
