Department of Otorhinolaryngology, Head and Neck Surgery, University of Turku and Turku University Hospital, Turku, Finland.
Acta Oncol. 2010;49(1):85-90. doi: 10.3109/02841860903287197.
High levels of certain matrix metalloproteinases (MMPs) have been detected in various human cancers. The purpose of this study was to analyze the expression of MMP-7 in salivary gland cancer (SGC) by immunohistochemistry and to associate the results with the clinical data and the 10-year survival of the SGC patients.
Immunohistochemistry for MMP-7 was performed in a series of 107 paraffin-embedded sections of SGC. The samples represent the entire SGC population in Finland from 1991-1996. Mortality follow-up ended December 31, 2006.
The study population of 107 patients consisted of 47 male and 60 female subjects, ranging in age at the time of diagnosis between 23 and 90 years. The minimum follow-up time was 10.6 years and the maximum 15.9 years. By age-adjusted analysis lower staining intensity was associated with worse overall survival of patients with acinic cell carcinoma (p = 0.047, HR 6.5, 95% Cl 1.0-41.7) and in mucoepidermoid carcinoma (p = 0.010, HR 9.3, 95% CI 1.7-50.0). Low staining intensity was also associated with worse disease-specific survival of patients with acinic cell carcinoma (0-1 vs. 2-3; p = 0.047, HR 13.7, 1.0-200.0). VCI Ki-67 was an important prognostic factor for survival of the entire data set (p < 0.0001, HR 4.7, 95% Cl 2.3-9.8).
MMP-7 is associated with the prognosis of patients with acinic cell and mucoepidermoid carcinoma.
在各种人类癌症中已检测到某些基质金属蛋白酶（MMP）水平升高。本研究的目的是通过免疫组织化学分析唾液腺癌（SGC）中 MMP-7 的表达，并将结果与 SGC 患者的临床数据和 10 年生存率相关联。
对来自 1991-1996 年芬兰的整个 SGC 人群的 107 例石蜡包埋切片进行 MMP-7 的免疫组织化学检测。截至 2006 年 12 月 31 日，对死亡率进行了随访。
107 例患者的研究人群包括 47 名男性和 60 名女性，诊断时年龄在 23 至 90 岁之间。最短随访时间为 10.6 年，最长为 15.9 年。通过年龄调整分析，低染色强度与腺样囊性癌（p = 0.047，HR 6.5，95%CI 1.0-41.7）和粘液表皮样癌（p = 0.010，HR 9.3，95%CI 1.7-50.0）患者的总体生存率较差相关。低染色强度也与腺样囊性癌患者的疾病特异性生存率较差相关（0-1 与 2-3；p = 0.047，HR 13.7，1.0-200.0）。VCI Ki-67 是整个数据集生存的重要预后因素（p < 0.0001，HR 4.7，95%CI 2.3-9.8）。
MMP-7 与腺样囊性癌和粘液表皮样癌患者的预后相关。
