Yildizbas Beyhan, Sahin H Guler, Kolusari Ali, Zeteroglu Sahin, Kamaci Mansur
Department of Obstetrics and Gynaecology, Yuzuncu Yil University, Van, Turkey.
Eur J Contracept Reprod Health Care. 2007 Sep;12(3):248-52. doi: 10.1080/13625180701442228.
To assess side effects during the first 6 months of use of Implanon.
The study was conducted in eastern Turkey between June 2004 and May 2005. Forty-one healthy women, aged 18-40 years who chose to use Implanon participated in the study. The implant was inserted between days 1 and 5 of the menstrual cycle. Findings were recorded before and during 6 months following insertion. Statistical analyses were performed using SPSS package programme including paired samples t-test.
No pregnancy occurred during the study. Ninety days after initiation of therapy, three of the 41 patients (7.3%) had regular periods, 14 (34.1%) were amenorrhoeic and the remaining 24 (58.5%) had some type of abnormal bleeding. Dysmenorrhoea affected significantly less women (1/41, i.e. 2.4%) than before treatment (17/41, i.e. 41.5%), but mastalgia increased significantly as it was reported by five previously unaffected participants (12.2%). Mood changes appeared in seven patients (17.1%) and acne in 11 of them (26.8%). The circulating levels of protein C, total cholesterol and oestradiol dropped significantly. Endometrial thickness decreased significantly. At completion of the study period, removal of the implant was requested by eight of the 41 patients (19.5%) because of irregular bleeding (six women), depressive symptoms requiring treatment (one woman) or weight gain (one woman).
Mainly because of irregular bleeding, the discontinuation rate of Implanon at 6 months among the women in this region is high (19.5%).
评估依伴侬植入使用最初6个月期间的副作用。
该研究于2004年6月至2005年5月在土耳其东部进行。41名年龄在18至40岁之间选择使用依伴侬的健康女性参与了研究。在月经周期的第1至5天植入该植入剂。在植入前及植入后6个月期间记录各项发现。使用SPSS软件包程序进行统计分析，包括配对样本t检验。
研究期间无妊娠发生。治疗开始90天后，41名患者中有3名（7.3%）月经规律，14名（34.1%）闭经，其余24名（58.5%）有某种类型的异常出血。痛经影响的女性明显少于治疗前（1/41，即2.4%，治疗前为17/41，即41.5%），但乳房疼痛显著增加，有5名之前未受影响的参与者报告出现此症状（12.2%）。7名患者（17.1%）出现情绪变化，其中11名（26.8%）出现痤疮。蛋白C、总胆固醇和雌二醇的循环水平显著下降。子宫内膜厚度显著降低。在研究期结束时，41名患者中有8名（19.5%）因不规则出血（6名女性）、需要治疗的抑郁症状（1名女性）或体重增加（1名女性）要求取出植入剂。
主要由于不规则出血，该地区女性中依伴侬在6个月时的停用率较高（19.5%）。
