丙型肝炎病毒1b型（HCV-1b）感染患者的肝细胞癌风险及丙型肝炎病毒NS3蛋白氨基末端的二级结构

Risk of hepatocellular carcinoma and secondary structure of hepatitis C virus (HCV) NS3 protein amino-terminus, in patients infected with HCV subtype 1b.

作者信息

Nishise Yuko, Saito Takafumi, Sugahara Kazuhiko, Ito Jun-Itsu, Saito Koji, Togashi Hitoshi, Nagano-Fujii Motoko, Hotta Hak, Kawata Sumio

机构信息

Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata 990-9585, Japan.

出版信息

J Infect Dis. 2007 Oct 1;196(7):1006-9. doi: 10.1086/521309. Epub 2007 Aug 23.

DOI:10.1086/521309

PMID:17763321

Abstract

We conducted a retrospective study of 65 patients with chronic hepatitis C, to determine whether the secondary structure of the amino-terminal 120 residues of the hepatitis C virus (HCV) NS3 protein is associated with an increased risk of development of hepatocellular carcinoma (HCC). The cumulative incidence of HCC was highest among patients infected with group B HCV-1b, wherein the risk of HCC significantly increased compared with that among patients infected with group A (hazard ratio, 4.95 [95% CI, 1.43-17.11]) after adjustment for age and histological stage. This HCV-1b grouping may be a useful marker for detecting the risk of development of HCC.

摘要

我们对65例慢性丙型肝炎患者进行了一项回顾性研究，以确定丙型肝炎病毒（HCV）NS3蛋白氨基末端120个残基的二级结构是否与肝细胞癌（HCC）发生风险增加相关。HCC的累积发病率在感染B组HCV-1b的患者中最高，在调整年龄和组织学分期后，与感染A组的患者相比，HCC风险显著增加（风险比，4.95 [95%CI，1.43 - 17.11]）。这种HCV-1b分组可能是检测HCC发生风险的一个有用标志物。