Zhang Jiangyang, van Zijl Peter C M, Laterra John, Salhotra Amandeep, Lal Bachchu, Mori Susumu, Zhou Jinyuan
Division of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Magn Reson Med. 2007 Sep;58(3):454-62. doi: 10.1002/mrm.21371.
Diffusion tensor imaging (DTI) is a new technique that uses the microscopic motion of water molecules to probe tissue 3D microstructures. In this study, high-resolution DTI was performed on rats bearing intracranial 9L gliosarcoma, F98 glioma, and human glioblastoma. It was found that the tumors consisted of central zones with low diffusion anisotropy and peripheral structures (rim) with high diffusion anisotropy. In the rims, water diffusion directionality formed a circular pattern for the 9L and F98 tumors, and a radial pattern for the human glioblastoma xenografts. These well-organized diffusion patterns appeared at an early stage postimplantation and continued to exist with tumor growth in all three models. High-resolution ex vivo imaging and histology confirmed the in vivo findings. These distinct patterns, undetectable with conventional MRI, may reflect tumor organization and growth patterns at the cellular level.
扩散张量成像（DTI）是一种利用水分子的微观运动来探测组织三维微观结构的新技术。在本研究中，对患有颅内9L胶质肉瘤、F98胶质瘤和人胶质母细胞瘤的大鼠进行了高分辨率DTI检查。结果发现，肿瘤由扩散各向异性低的中心区和扩散各向异性高的周边结构（边缘）组成。在边缘区，9L和F98肿瘤的水扩散方向性形成圆形模式，而人胶质母细胞瘤异种移植物的水扩散方向性形成放射状模式。这些组织良好的扩散模式在植入后早期出现，并在所有三种模型中随着肿瘤生长持续存在。高分辨率离体成像和组织学证实了体内研究结果。这些传统MRI无法检测到的独特模式可能反映了细胞水平上的肿瘤组织和生长模式。
