木棉中的倍半萜类化合物。

Sesquiterpenoids from Bombax malabaricum.

作者信息

Zhang Xiaohui, Zhu Huilin, Zhang Shuwei, Yu Qiang, Xuan Lijiang

机构信息

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Science, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.

出版信息

J Nat Prod. 2007 Sep;70(9):1526-8. doi: 10.1021/np070256j. Epub 2007 Sep 1.

DOI:10.1021/np070256j

PMID:17764148

Abstract

Phytochemical investigation of the chemical constituents of the roots of Bombax malabaricum afforded nine cadinane sesquiterpenoids, including five new compounds (bombamalones A-D, 1-4; bombamaloside, 5), and four known compounds (isohemigossypol-1-methyl ester, 6; 2-O-methylisohemigossylic acid lactone, 7; bombaxquinone B, 8; and lacinilene C, 9). The structures of 1-5 were identified by spectroscopic methods and comparison with literature values. Compounds 1-9 were evaluated against the HGC-27 human gastrointestinal cancer cell line, but all were inactive (IC(50) >10 microM).

摘要

对木棉根的化学成分进行植物化学研究，得到了9种杜松烷倍半萜类化合物，包括5个新化合物（木棉内酯A - D，1 - 4；木棉苷，5）和4个已知化合物（异半棉酚-1-甲酯，6；2-O-甲基异半棉酚酸内酯，7；木棉醌B，8；和刺苞菊内酯C，9）。通过光谱方法并与文献值比较确定了1 - 5的结构。对化合物1 - 9针对HGC - 27人胃肠道癌细胞系进行了评估，但所有化合物均无活性（IC(50) >10 microM）。