菊苣素 D-F： 和 的三种新化合物及其生物活性。
Cichorins D-F: Three New Compounds from and Their Biological Effects.
机构信息
Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
出版信息
Molecules. 2020 Sep 11;25(18):4160. doi: 10.3390/molecules25184160.
L., (chicory) is employed in various traditional medicines to treat a wide range of diseases and disorders. In the current investigation, two new naphthalane derivatives viz., cichorins D () and E (), along with one new anthraquinone cichorin F (), were isolated from In addition, three previously reported compounds viz., β-sitosterol (), β-sitosterol β-glucopyranoside (), and stigmasterol () were also isolated from Their structures were established via extensive spectroscopic data, including 1D (H and C) and 2D NMR (COSY, HSQC and HMBC), and ESIMS. Cichorin E () has a weak cytotoxic effect on breast cancer cells (MDA-MB-468: IC: 85.9 µM) and Ewing's sarcoma cells (SK-N-MC: IC: 71.1 µM); cichorin F () also illustrated weak cytotoxic effects on breast cancer cells (MDA-MB-468: IC: 41.0 µM and MDA-MB-231: IC: 45.6 µM), and SK-N-MC cells (IC: 71.9 µM). Moreover compounds - did not show any promising anthelmintic effects.
L.，（菊苣）被用于各种传统药物中，以治疗多种疾病和失调。在当前的研究中，从 中分离得到了两种新的萘烷衍生物，即菊苣素 D()和 E()，以及一种新的蒽醌菊苣素 F()。此外，还从 中分离得到了三种先前报道的化合物，即β-谷甾醇()、β-谷甾醇-β-吡喃葡萄糖苷()和豆甾醇()。它们的结构通过广泛的光谱数据确定，包括 1D (H 和 C) 和 2D NMR (COSY、HSQC 和 HMBC) 和 ESIMS。菊苣素 E()对乳腺癌细胞 (MDA-MB-468：IC: 85.9 µM) 和尤因肉瘤细胞 (SK-N-MC：IC: 71.1 µM) 具有较弱的细胞毒性；菊苣素 F()对乳腺癌细胞 (MDA-MB-468：IC: 41.0 µM 和 MDA-MB-231：IC: 45.6 µM) 和 SK-N-MC 细胞 (IC: 71.9 µM) 也表现出较弱的细胞毒性。此外，化合物- 没有表现出任何有前途的驱虫效果。
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