黄花蒿中二聚倍半萜及倍半萜类化合物。
Dimeric guaianolides and sesquiterpenoids from Artemisia anomala.
机构信息
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, People's Republic of China.
出版信息
J Nat Prod. 2010 Jan;73(1):67-70. doi: 10.1021/np900462u.
A new dimeric guaianolide (8) and a new glaucolide (3), a seco-guaiaretic acid (4), two guaianolides (6 and 7), and five known sesquiterpene lactones (1, 2, 5, 9, and 10) were isolated from the aerial part of Artemisia anomala. Their structures were determined on the basis of chemical and spectroscopic analysis. In addition, their cytotoxic activities against five human cancer cell lines and anti-COX-2 effects in vitro were evaluated.
从异常蒿 Artemisia anomala 的地上部分分离得到一个新的二聚愈创木烷内酯（8）和一个新的愈创木内酯（3），一个去甲愈创木酸（4），两个愈创木烷内酯（6 和 7），以及五个已知的倍半萜内酯（1、2、5、9 和 10）。根据化学和光谱分析确定了它们的结构。此外，还评估了它们对五种人癌细胞系的细胞毒性活性和体外抗 COX-2 作用。
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