木棉花朵中的酚类化合物及其抗氧化和抗病毒活性
Phenolic Compounds from the Flowers of Bombax malabaricum and Their Antioxidant and Antiviral Activities.
作者信息
Zhang Yu-Bo, Wu Peng, Zhang Xiao-Li, Xia Chao, Li Guo-Qiang, Ye Wen-Cai, Wang Guo-Cai, Li Yao-Lan
机构信息
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
Shenzhen Engineering Laboratory of Lingnan Herbal Resource Development and Application, Shenzhen Institute for Drug Control, Shenzhen 518057, China.
出版信息
Molecules. 2015 Nov 5;20(11):19947-57. doi: 10.3390/molecules201119660.
Three new phenolic compounds 1-3 and twenty known ones 4-23 were isolated from the flowers of Bombax malabaricum. Their chemical structures were elucidated by spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1D- and 2D-NMR) and chemical reactions. The antioxidant capacities of the isolated compounds were tested using FRAP and DPPH radical-scavenging assays, and compounds 4, 6, 8, 12, as well as the new compound 2, exhibited stronger antioxidant activities than ascorbic acid. Furthermore, all of compounds were tested for their antiviral activities against RSV by the CPE reduction assay and plaque reduction assay. Compounds 4, 10, 12 possess in vitro antiviral activities, and compound 10 exhibits potent anti-RSV effects, comparable to the positive control ribavirin.
从木棉的花朵中分离出了三种新的酚类化合物1-3以及二十种已知化合物4-23。通过光谱分析（红外光谱、电喷雾电离质谱、高分辨电喷雾电离质谱、一维和二维核磁共振）和化学反应阐明了它们的化学结构。使用铁离子还原抗氧化能力（FRAP）和二苯基苦味酰基自由基清除（DPPH）测定法测试了分离出的化合物的抗氧化能力，化合物4、6、8、12以及新化合物2表现出比抗坏血酸更强的抗氧化活性。此外，通过细胞病变效应减少测定法和蚀斑减少测定法测试了所有化合物对呼吸道合胞病毒（RSV）的抗病毒活性。化合物4、10、12具有体外抗病毒活性，化合物10表现出强效的抗RSV作用，与阳性对照利巴韦林相当。
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