Martelletti P
Centro Cefalee, Università La Sapienza, Roma, Italia.
Acta Neurol (Napoli). 1991 Oct;13(5):448-56.
We studied a group of migraine patients for circulating immune complexes, lymphocyte subpopulations, IgG4 and anti-IgG antibodies, before, after 4 hours and after 72 hours a specific challenge test. We found an increased incidence of circulating immune complexes. Total T cells showed a marked increase after challenge test. The most important finding was the presence of T-activated cells. Also K and NK cells showed an early increase after the challenge. In commenting the outcomes of this investigation, it must be stressed that the evidence of an early lymphocyte activation after the challenge test indicates an involvement of interleukin-2 related receptor in food-induced migraine. The results have reinforced the idea of immune mechanism involvement in food-induced migraine, but it seems to be localized at different step from that until now hypothesized, with the involvement of the complex cytokines network.
我们对一组偏头痛患者在特定激发试验前、4小时后和72小时后进行了循环免疫复合物、淋巴细胞亚群、IgG4和抗IgG抗体的研究。我们发现循环免疫复合物的发生率增加。总T细胞在激发试验后显著增加。最重要的发现是存在T激活细胞。此外，K细胞和NK细胞在激发后早期也出现增加。在评论这项研究的结果时，必须强调的是，激发试验后早期淋巴细胞激活的证据表明白细胞介素-2相关受体参与了食物诱发的偏头痛。这些结果强化了免疫机制参与食物诱发偏头痛的观点，但似乎其定位在与迄今所假设的不同阶段，涉及复杂的细胞因子网络。
