Taniguchi Ryousuke, Higuchi Tsuyoshi, Mizunuma Hideki
Hirosaki university school of medicine, Department of Obstetrics and Gynecology, Japan.
Clin Calcium. 2007 Sep;17(9):1342-8.
Estrogen depletion after menopause become involved with postmenopausal bone loss, therefore ET (estrogen therapy) and EPT (estrogen-progestogen therapy) have been considered as first-line therapy for postmenopausal osteopenia and osteoporosis. However, after WHI (Women's Health Initiative) reports, use of estrogen for treatment of osteopenia and osteoporosis is limited. Because estrogen plays indispensable roles in maintaining female physiological functions including bone metabolism, use of estrogens would elicit much benefits when administered properly.
绝经后雌激素缺乏与绝经后骨质流失有关，因此雌激素疗法（ET）和雌激素 - 孕激素疗法（EPT）一直被视为绝经后骨质减少和骨质疏松症的一线治疗方法。然而，在妇女健康倡议（WHI）报告发布后，雌激素用于治疗骨质减少和骨质疏松症的应用受到了限制。由于雌激素在维持包括骨代谢在内的女性生理功能中起着不可或缺的作用，适当使用雌激素会带来诸多益处。
