Carraro S, Gottardi G, Bonetto G, Baraldi E
Department of Pediatrics, University of Padova, Padova, Italy.
Pediatr Allergy Immunol. 2007 Nov;18 Suppl 18:28-30. doi: 10.1111/j.1399-3038.2007.00629.x.
Exhaled nitric oxide (FE(NO)) is a surrogate marker of eosinophilic airway inflammation. The measurement of this gas can be easily performed in children and the result is immediately available. Because of these characteristics, measurement of FE(NO) is slowly becoming part of the routine clinical evaluation of an asthmatic patient. FE(NO) measurement may have a role both in the diagnosis of asthma and as a guide in therapy algorithms. For example when FE(NO) levels are persistently normal and the asthmatic child is asymptomatic, the steroid therapy may be decreased or even stopped. In patients with acute or chronic rhinosinusitis the levels of nasal nitric oxide (nNO) are significantly decreased, while they rise up after a course of antibiotics. The measurement of nasal NO has been proposed as a functional test to evaluate sinus ventilation. Nasal NO is significantly reduced also in primary ciliary dyskinesia and can be used as a screening tool to identify patients affected by this condition.
呼出一氧化氮（FE(NO)）是嗜酸性气道炎症的替代标志物。这种气体的测量在儿童中很容易进行，并且结果可立即获得。由于这些特性，FE(NO)测量正逐渐成为哮喘患者常规临床评估的一部分。FE(NO)测量在哮喘诊断和治疗方案指导中都可能发挥作用。例如，当FE(NO)水平持续正常且哮喘儿童无症状时，可减少甚至停用类固醇治疗。在急性或慢性鼻窦炎患者中，鼻一氧化氮（nNO）水平显著降低，而在一个疗程的抗生素治疗后会升高。鼻NO测量已被提议作为评估鼻窦通气的功能测试。在原发性纤毛运动障碍中鼻NO也显著降低，可作为识别受此疾病影响患者的筛查工具。
