Zinelli C, Caffarelli C, Strid J, Jaffe A, Atherton D J
Department of Human Development, Paediatric Clinic, University of Parma, Parma, Italy.
Clin Exp Dermatol. 2009 Jul;34(5):607-12. doi: 10.1111/j.1365-2230.2008.03142.x.
Children with atopic eczema (AE) are at risk of developing asthma. Airway inflammation has been shown to be present before the onset of clinical asthma. Increased exhalation (forced expiration; FE) of nitric oxide (FE(NO)) and 8-isoprostane seems to be a feature of bronchial inflammation in people with asthma.
To determine whether the exhalation of these two molecules is increased in children with eczema, even in the absence of overt asthma.
In total, 21 children with AE were recruited and compared with healthy controls. A questionnaire was completed to identify respiratory symptoms compatible with asthma. The severity of AE was graded clinically. Spirometry, FE(NO) measurements and exhaled breath condensate collection for 8-isoprostane were performed.
The mean level of 8-isoprostane was similar for children with AE (2.33 +/- 4.76 pg/mL) and controls (3.37 +/- 3.43). FE(NO) was increased in children with AE (mean 64.97 parts per billion) compared with the normal range, even in the absence of respiratory symptoms and in the presence of normal lung function.
FE(NO) but not 8-isoprostane levels in exhaled breath condensate are higher in children with AE without asthma. Our finding may indicate a predictive role for FE(NO) for the development of asthma.
患有特应性皮炎（AE）的儿童有患哮喘的风险。气道炎症在临床哮喘发作前就已存在。呼出一氧化氮（FE(NO)）和8-异前列腺素增加似乎是哮喘患者支气管炎症的一个特征。
确定即使在没有明显哮喘的情况下，湿疹患儿呼出的这两种分子是否增加。
总共招募了21名AE患儿，并与健康对照进行比较。完成一份问卷以确定与哮喘相符的呼吸道症状。临床对AE的严重程度进行分级。进行肺功能测定、FE(NO)测量以及收集呼出气体冷凝物以检测8-异前列腺素。
AE患儿（2.33±4.76 pg/mL）和对照组（3.37±3.43）的8-异前列腺素平均水平相似。与正常范围相比，AE患儿的FE(NO)增加（平均64.97 ppb），即使在没有呼吸道症状且肺功能正常的情况下也是如此。
在没有哮喘的AE患儿中，呼出气体冷凝物中的FE(NO)水平升高，而8-异前列腺素水平未升高。我们的发现可能表明FE(NO)对哮喘发展具有预测作用。
