Suzuki Miwa, Endo Naoko, Nakano Yuichi, Kato Haruhiko, Kishiro Toshiya, Asahina Kiyoshi
Department of Marine Science and Resources, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
J Comp Physiol B. 2008 Feb;178(2):149-56. doi: 10.1007/s00360-007-0204-1. Epub 2007 Sep 2.
This study examined the distribution pattern of aquaporin-2 (AQP2), relative medullary thickness (RMT) and urine properties in the bottlenose dolphin Tursiops truncatus and Baird's beaked whale Berardius bairdii. Immunohistochemical studies revealed that AQP2 was localized in the collecting tubules/ducts of both species' renicules, as in terrestrial mammals. The collecting ducts with AQP2 were thinner and arranged more densely in the dolphin than in the whale. RMT values in the renicule were moderate in both species, but were significantly higher in the dolphin (6.0 +/- 0.9) than the whale (4.9 +/- 0.7). Urine of the bottlenose dolphin is comparatively concentrated (osmolality: 1715.7 +/- 279.4 mOsm kg(-1), Na(+): 490.1 +/- 87.9 mmol l(-1), Cl(-): 402.7 +/- 79.6 mmol l(-1), K(+): 80.7 +/- 25.8 mmol l(-1), urea nitrogen: 703.5 +/- 253.9 mmol l(-1)), while urine of the dead Baird's beaked whale is less concentrated (osmolality: 837.5 +/- 293.8 mOsm kg(-1), Na(+): 192.9 +/- 81.5 mmol l(-1), Cl(-): 159.9 +/- 71.4 mmol l(-1), K(+): 44.3 +/- 29.5 mmol l(-1), urea nitrogen: 270.7 +/- 120.3 mmol l(-1)). These data suggest it is possible that the differences in these renal morphological features may be related in some way to the difference in urine composition between the species, although further studies are necessary.
本研究调查了宽吻海豚（Tursiops truncatus）和贝氏喙鲸（Berardius bairdii）中aquaporin - 2（AQP2）的分布模式、相对髓质厚度（RMT）及尿液特性。免疫组织化学研究显示，与陆生哺乳动物一样，AQP2定位于这两个物种肾小叶的集合小管/集合管中。含有AQP2的集合管在海豚中比在鲸中更细且排列更密集。两个物种肾小叶中的RMT值均为中等，但海豚（6.0±0.9）显著高于鲸（4.9±0.7）。宽吻海豚的尿液相对浓缩（渗透压：1715.7±279.4 mOsm kg(-1)，Na(+)：490.1±87.9 mmol l(-1)，Cl(-)：402.7±79.6 mmol l(-1)，K(+)：80.7±25.8 mmol l(-1)，尿素氮：703.5±253.9 mmol l(-1)），而死亡的贝氏喙鲸的尿液浓缩程度较低（渗透压：837.5±293.8 mOsm kg(-1)，Na(+)：192.9±81.5 mmol l(-1)，Cl(-)：159.9±71.4 mmol l(-1)，K(+)：44.3±29.5 mmol l(-1)，尿素氮：270.7±120.3 mmol l(-1)）。这些数据表明，尽管需要进一步研究，但这些肾脏形态特征的差异可能在某种程度上与物种间尿液成分的差异有关。
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