Johnson B A, Anker H, Meleney F L
Science. 1945 Oct 12;102(2650):376-7. doi: 10.1126/science.102.2650.376.
A new antibiotic "bacitracin" has been recovered from a strain of the B. subtilis group of organisms. It is neutral, water-soluble, non-toxic and relatively heat stable. In vitro it is active chiefly against Grampositive organisms, but the gonococcus and meningococcus are susceptible to its action. It is also active in vivo against experimentally produced hemolytic streptococcal infections in mice and gas gangrene infections in guinea pigs. Clinical use in hemolytic streptococcal and staphylococcal infections in man have given encouraging results.
一种新的抗生素“杆菌肽”已从一株枯草芽孢杆菌属的微生物中分离出来。它呈中性,可溶于水,无毒且相对耐热。在体外,它主要对革兰氏阳性菌有活性,但淋球菌和脑膜炎球菌也对其作用敏感。在体内,它对小鼠实验性产生的溶血性链球菌感染和豚鼠气性坏疽感染也有活性。在人类溶血性链球菌和葡萄球菌感染中的临床应用已取得了令人鼓舞的结果。