Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology (NUST), Islamabad 44000, Pakistan.
Department of Biochemistry, Abdul Wali Khan University Mardan (AWKUM), Mardan 23200, Pakistan.
Molecules. 2023 Jan 17;28(3):927. doi: 10.3390/molecules28030927.
Despite their remarkable biosynthetic potential, have been widely overlooked. However, their capability to withstand harsh conditions (extreme temperature, Ultraviolet (UV) and γ-radiation, and dehydration) and the promiscuous metabolites they synthesize have created increased commercial interest in them as a therapeutic agent, a food preservative, and a plant-pathogen control agent. Nevertheless, the commercial-scale availability of these metabolites is constrained due to challenges in their accessibility via synthesis and low fermentation yields. In the context of this rising in interest, we comprehensively visualized the antimicrobial peptides produced by and highlighted their prospective applications in various industries. Moreover, we proposed and classified these metabolites produced by the group based on their biosynthetic pathways and chemical structures. The biosynthetic pathway, bioactivity, and chemical structure are discussed in detail for each class. We believe that this review will spark a renewed interest in the often disregarded and its remarkable biosynthetic capabilities.
尽管具有显著的生物合成潜力，但 一直被广泛忽视。然而，它们能够承受恶劣的条件（极端温度、紫外线 (UV) 和 γ 辐射以及脱水），并且它们合成的代谢物混杂，这使得它们作为治疗剂、食品防腐剂和植物病原体控制剂的商业兴趣增加。然而，由于通过合成获得这些代谢物的难度以及发酵产量低，这些代谢物的商业规模可用性受到限制。在这种兴趣上升的背景下，我们全面可视化了 产生的抗菌肽，并强调了它们在各个行业中的潜在应用。此外，我们根据 组的生物合成途径和化学结构对这些代谢物进行了分类。对每个类别都详细讨论了其生物合成途径、生物活性和化学结构。我们相信，这篇综述将重新激发人们对经常被忽视的 和其卓越的生物合成能力的兴趣。
