Mayevsky A
J Neurosci Res. 1975;1(2):131-42. doi: 10.1002/jnr.490010205.
The use of trimethadione (TMO) as a protector in hyperbaric oxygen toxicity in the conscious rat has been examined in detail. The oxidation-reduction state of pyridine nucleotides was measured simultaneously with the EEG activity from the surface of the brain cortex. From the data obtained, a few parameters were calculated. The results show that in TMO-treated animals the time to the onset of convulsions, the time to the onset of NADH oxidation-reduction cycles, and the survival time were significantly longer than in the control group. The effect of TMO on the EEG shows that the tonic phase of the convulsive activity was almost completely abolished.
已详细研究了三甲双酮（TMO）在清醒大鼠高压氧中毒中作为保护剂的应用。同时测量了大脑皮层表面的脑电图活动以及吡啶核苷酸的氧化还原状态。根据获得的数据计算了一些参数。结果表明，在接受TMO治疗的动物中，惊厥发作时间、NADH氧化还原循环开始时间和存活时间均显著长于对照组。TMO对脑电图的影响表明，惊厥活动的强直期几乎完全消失。
