Meyer Urs A
Biozentrum, University of Basel, Basel, Switzerland.
Drug Metab Rev. 2007;39(2-3):639-46. doi: 10.1080/03602530701498737.
Evolution has provided organisms with an elaborate defense system against foreign compounds and against the accumulation of potentially toxic endogenous molecules, e.g. bile acids. Cytochromes P450 represent an important group of enzymes in this system. This article describes experiments started in the 1970's in Dallas on the coordination of heme and cytochrome P450 synthesis and how these studies evolved over the years into a concept of molecular links between xenobiotic metabolism and endogenous pathways of sterol, lipid, bile acid and energy homeostasis.
进化为生物体提供了一套精密的防御系统，以抵御外来化合物以及潜在有毒内源性分子（如胆汁酸）的积累。细胞色素P450是该系统中的一类重要酶。本文描述了20世纪70年代在达拉斯开展的关于血红素与细胞色素P450合成协调作用的实验，以及这些研究多年来如何演变成关于外源性物质代谢与甾醇、脂质、胆汁酸内源性途径及能量稳态之间分子联系的概念。
