杜纳霉素，一种具有免疫抑制活性的新型螺旋酮24元大环内酯类化合物。I. 产生菌的分类学、发酵及抗菌活性
Dunaimycins, a new complex of spiroketal 24-membered macrolides with immunosuppressive activity. I. Taxonomy of the producing organisms, fermentation and antimicrobial activity.
作者信息
Karwowski J P, Jackson M, Maus M L, Kohl W L, Humphrey P E, Tillis P M
机构信息
Pharmaceutical Products Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064.
出版信息
J Antibiot (Tokyo). 1991 Dec;44(12):1312-7. doi: 10.7164/antibiotics.44.1312.
PMID:1778784
Abstract
The dunaimycins are a new complex of spiroketal 24-membered macrolides discovered in the fermentation broth of two actinomycetes. Based on taxonomic studies these two cultures, which were isolated from soil, were identified as Streptomyces diastatochromogenes strains AB 1691Q-321 and AB 1711J-452. The dunaimycins possess both immunosuppressive and antimicrobial activity.
摘要
杜纳霉素是从两种放线菌的发酵液中发现的一种新的螺旋酮24元大环内酯类化合物。基于分类学研究，这两种从土壤中分离出的培养物被鉴定为产二色链霉菌菌株AB 1691Q - 321和AB 1711J - 452。杜纳霉素具有免疫抑制和抗菌活性。
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