Matsuda T, Tanaka H, Williams S, Hanumadass M, Abcarian H, Reyes H
Burn Center, Cook County Hospital, Chicago, IL 60612.
J Burn Care Rehabil. 1991 Nov-Dec;12(6):525-32. doi: 10.1097/00004630-199111000-00007.
The effects of high-dose vitamin C therapy (170 mg, 340 mg, and 680 mg/kg/day) were evaluated in 70% body surface area third-degree burns in guinea pigs that were resuscitated with 1 ml/kg/%burn Ringer's lactate solution. The water content measurements of the burned skin at 24 hours after burn injury in the vitamin C-treated groups were significantly lower than those of the control group (1 ml/kg/%burn) and those of the standard resuscitation group (4 ml/kg/%burn). The cardiac outputs in the group that received 340 mg vitamin C were significantly higher than those of the control group but not significantly different than those of the standard therapy group at 2 hours after burn injury and thereafter. In comparison with the regimen of 340 mg vitamin C, the regimen of 680 mg vitamin C was no more beneficial, and the regimen of 170 mg was less effective. With administration of adjuvant high-dose vitamin C, we were able to reduce the total 24-hour resuscitation volume from 4 ml/kg/%burn to 1 ml/kg/%burn, while a comparable cardiac output was maintained.
在采用1 ml/kg/%烧伤乳酸林格氏液进行复苏的豚鼠身上，评估了高剂量维生素C疗法（170 mg、340 mg和680 mg/kg/天）对70%体表面积三度烧伤的影响。维生素C治疗组在烧伤后24小时测量的烧伤皮肤含水量显著低于对照组（1 ml/kg/%烧伤）和标准复苏组（4 ml/kg/%烧伤）。接受340 mg维生素C的组在烧伤后2小时及之后的心输出量显著高于对照组，但与标准治疗组无显著差异。与340 mg维生素C方案相比，680 mg维生素C方案并无更多益处，而170 mg方案效果较差。通过给予辅助性高剂量维生素C，我们能够将24小时总复苏液量从4 ml/kg/%烧伤减少至1 ml/kg/%烧伤，同时维持相当的心输出量。
