Science. 1968 Feb 16;159(3816):739-41. doi: 10.1126/science.159.3816.739.
By outbreeding Wistar rats and selecting for breeding animals that differ in their alcohol consumption, we have raised two genetically different lines. Marked differences between the sexes and the strains were evident by the eighth generation. Selection is reflected in the regression coefficient .754, which accounts for 65.9 percent of the variance. The heritabilities differ significantly in the two sexes, h2 for the males being .263, and for the females .371; this difference seems mainly ascribable to sex-linkage of some of the genetic factors controlling voluntary consumption of alcohol.
通过对 Wistar 大鼠进行杂交，并选择在酒精摄入量上存在差异的繁殖动物，我们培育出了两个具有遗传差异的品系。到第八代时，雄性和雌性之间以及不同品系之间的明显差异就已经显现出来了。选择反映在回归系数.754 上，它解释了 65.9%的方差。两个性别之间的遗传力差异显著，雄性的 h2 为.263，雌性的 h2 为.371；这种差异似乎主要归因于控制自愿饮酒的某些遗传因素的性连锁。
