Korinteli M O, Metelitsa V I, Ostrovskaia T P, Duda S G, Vygodin V A
Kardiologiia. 1991 Jul;31(7):33-6.
The single doses of three reference antihypertensive drugs: corinfar (20 mg), anapriline (80 mg), and hypothiazide (50 mg) were screened on day 5 of drug administration at rest and during paired isometric and dynamic exercises in comparison to placebo. There was a significant decrease in blood pressures: systolic (SBP), diastolic (DBP), and mean (MBP) (p less than 0.01-0.001) at rest and during isometric and dynamic exercises after single doses of corinfar and hypothiazide versus placebo. A single dose of anapriline resulted in a significant reduction in SBP and MBP at rest and during dynamic exercise (p less than 0.05-0.001), in DBP at rest (p less than 0.05) and in an insignificant decrease in SBP, DBP, and MBP during isometric exercise and DBP during dynamic exercise. The agents were graded in terms of the effect of placebo from the mean group and individual hypotensive effects (by each blood pressure parameter). The resting dynamic exercise failed to yield some new evidence for determining the efficacy of corinfar and hypothiazide, whereas it was informative for anapriline with regard to SBP. With respect to SBP, DBP, and MBP, isometric exercise was informative for hypothiazide.
在给药第5天，在静息状态以及等长和动态运动配对时，将三种参考抗高血压药物的单剂量：可利福（20毫克）、心得安（80毫克）和氢氯噻嗪（50毫克）与安慰剂进行比较筛选。与安慰剂相比，单剂量可利福和氢氯噻嗪后，静息状态以及等长和动态运动时血压显著降低：收缩压（SBP）、舒张压（DBP）和平均血压（MBP）（p小于0.01 - 0.001）。单剂量心得安导致静息状态和动态运动时SBP和MBP显著降低（p小于0.05 - 0.001），静息时DBP显著降低（p小于0.05），等长运动时SBP、DBP和MBP以及动态运动时DBP有不显著降低。根据安慰剂组的平均效应和个体降压效应（按每个血压参数）对这些药物进行分级。静息动态运动未能为确定可利福和氢氯噻嗪的疗效提供新证据，而对于心得安的SBP而言该运动有参考价值。就SBP、DBP和MBP而言，等长运动对氢氯噻嗪有参考价值。
