Korinteli M O, Metelitsa V I, Ostrovskaia T P, Vygodin V A
Kardiologiia. 1991 Mar;31(3):57-61.
The paper presents the results of the study into the efficacy of single routine doses of essential antihypertensive agents (nifedipine, propranolol, and hydrochlorothiazide) versus its course treatment at rest and during isometric and dynamic exercise tests. The efficacy was assessed by using the Dixon criterion. The routine drug dose tests performed at rest and during isometric and dynamic exercise were shown to have a varying informative value in the prediction of long-term treatment with the above drugs. The isometric and dynamic exercise tests are of the greatest significance in the evaluation of the antihypertensive routine dose of nifedipine, whereas the dynamic exercise test alone is of value for propranolol and the rest exercise test, the both exercise tests for hydrochlorothiazide. Thus, the results of the corresponding routine drug dose tests are of varying predictive informative value, which is essential both for choosing an effective drug and for making an objective assessment of the outcomes of the course therapy.
本文介绍了关于单一常规剂量的基本抗高血压药物（硝苯地平、普萘洛尔和氢氯噻嗪）与静息状态以及等长和动态运动试验期间的疗程治疗效果的研究结果。疗效采用狄克逊标准进行评估。结果表明，在静息状态以及等长和动态运动期间进行的常规药物剂量试验，在预测上述药物的长期治疗效果方面具有不同的信息价值。等长和动态运动试验在评估硝苯地平的抗高血压常规剂量方面意义最大，而单独的动态运动试验对普萘洛尔有价值，静息运动试验对氢氯噻嗪有价值，两种运动试验对氢氯噻嗪都有价值。因此，相应常规药物剂量试验的结果具有不同的预测信息价值，这对于选择有效药物以及客观评估疗程治疗的结果都至关重要。
