Lorenz R T, Parks L W
Department of Microbiology, North Carolina State University, Raleigh 27695-7615.
Lipids. 1991 Aug;26(8):598-603. doi: 10.1007/BF02536423.
There is an intimate association between sterol biosynthesis in yeast and aerobicity. Besides the requirement for molecular oxygen for the epoxidation of squalene, cytochrome hemoproteins are involved in demethylation and desaturation steps. Regulatory effects of hemes on sterol formation have been demonstrated using specifically defective mutants of yeast. Heme competency participates in a mechanism whereby wild-type cells are prevented from taking exogenous sterols from the growth media. The multiple interactions of hemes and sterols appear to be associated with the variously defined functions for sterols in the yeast cells.
酵母中甾醇生物合成与需氧性之间存在密切联系。除了角鲨烯环氧化需要分子氧外，细胞色素血红素蛋白还参与去甲基化和去饱和步骤。利用酵母的特定缺陷突变体已证明血红素对甾醇形成的调节作用。血红素能力参与了一种机制，通过该机制野生型细胞被阻止从生长培养基中摄取外源性甾醇。血红素与甾醇的多种相互作用似乎与酵母细胞中甾醇的各种不同定义的功能相关。
