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脊髓神经元的再生:神经生长因子给药后的蛋白质合成。

Regeneration in spinal neurons: proteosynthesis following nerve growth factor administration.

出版信息

Science. 1966 May 6;152(3723):787-8. doi: 10.1126/science.152.3723.787.

DOI:10.1126/science.152.3723.787
PMID:17797458
Abstract

Incorporation of H(3)-leucine into dorsal root ganglion cells in rats was markedly increased over that of controls following section of sciatic and femoral nerves. Crush lesion of dorsal roots did not increase the H(3)-leucine uptake of these cells except in animals which had received nerve growth factor after the operation.

摘要

结扎大鼠坐骨神经和股神经后,其背根神经节细胞摄取 H(3)-亮氨酸的能力明显高于对照组。背根挤压伤除了在手术后给予神经生长因子的动物外,并不增加这些细胞对 H(3)-亮氨酸的摄取。

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引用本文的文献

1
Protein turnover during maturation of mouse brain tissue.小鼠脑组织成熟过程中的蛋白质周转
J Cell Biol. 1972 Apr;53(1):143-7. doi: 10.1083/jcb.53.1.143.
2
Effects of forelimb amputation and denervation on protein synthesis in spinal cord ganglia of the newt.前肢截肢和去神经支配对蝾螈脊髓神经节中蛋白质合成的影响。
Proc Natl Acad Sci U S A. 1986 Oct;83(20):7971-4. doi: 10.1073/pnas.83.20.7971.
3
Altered expression of neuronal cell adhesion molecules induced by nerve injury and repair.神经损伤与修复诱导的神经元细胞黏附分子表达改变
J Cell Biol. 1986 Sep;103(3):929-45. doi: 10.1083/jcb.103.3.929.
4
Enhanced labeling of a retinal protein during regeneration of optic nerve in goldfish.金鱼视神经再生过程中视网膜蛋白标记增强。
Proc Natl Acad Sci U S A. 1976 Mar;73(3):828-32. doi: 10.1073/pnas.73.3.828.
5
Membrane properties and conduction velocity in sensory neurones following central or peripheral axotomy.中枢或外周轴突切断后感觉神经元的膜特性和传导速度
J Physiol. 1977 Aug;270(1):165-80. doi: 10.1113/jphysiol.1977.sp011944.