肺中 N-异丙基-123I-对碘安非他明的摄取机制——它是否取决于 pH、亲脂性或 pKa？
N-isopropyl-123I-p-iodoamphetamine uptake mechanism in the lung--is it dependent on pH, lipophilicity or pKa?
作者信息
Akber S F
机构信息
Department of Radiology, University of Texas Medical School, Houston.
出版信息
Nuklearmedizin. 1991 Dec;30(6):294-6.
PMID:1780245
Abstract
The uptake and binding mechanism of biogenic amines in the lungs has been studied extensively with no conclusive results. The competition between N-isopropyl-123I-p-iodo amphetamines (123I-IMP) and propranolol and 123I-IMP and ketamine, in the lungs suggest that the pKa value of the biogenic amines has a significant role to play in the mechanism of uptake and retention of biogenic amines in the lungs.
摘要
肺部生物胺的摄取和结合机制已得到广泛研究，但尚无定论。肺部中 N-异丙基-123I-对碘安非他明（123I-IMP）与普萘洛尔以及 123I-IMP 与氯胺酮之间的竞争表明，生物胺的 pKa 值在肺部生物胺的摄取和潴留机制中起着重要作用。
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