Holman B L, Zimmerman R E, Schapiro J R, Kaplan M L, Jones A G, Hill T C
J Nucl Med. 1983 Oct;24(10):922-31.
The biodistribution of N-isopropyl-p-[123I]iodoamphetamine (I-123 IMP) in the Macaca fascicularis monkey was determined at 15 min and at 1, 4, 24, and 48 hr after intravenous injection. Brain uptake was 7.8% of the injected dose at 1 hr, with little change in concentration between 15 min and 1 hr, falling thereafter. Eye uptake reached a maximum of 0.23% of injected dose at 24 hr, with activity primarily in the pigmented layers. The human absorbed radiation dose was calculated on the basis of biodistribution data. The critical organ is the eye (0.407 rad/mCi of I-123 IMP). The eye dose increased to 1.11 rad/mCi with 4% contamination from I-124 IMP and to 0.535 rad/mCi with 0.4% contamination from I-125 IMP. The absorbed dose to the liver was 0.127 rad/mCi for pure I-123 IMP and the thyroid dose was 0.120 rad/mCi, both increasing with either I-124 or I-125 contamination. While delayed eye uptake has not yet been reported in the human, care should be exercised in limiting the amount of contaminating I-124 or I-125 to the lowest practical level.
在食蟹猴静脉注射 N-异丙基-p-[¹²³I]碘安非他明（I-123 IMP）后 15 分钟以及 1、4、24 和 48 小时，测定了其生物分布。1 小时时脑摄取量为注射剂量的 7.8%，15 分钟至 1 小时之间浓度变化不大，此后下降。眼部摄取在 24 小时时达到注射剂量的 0.23%最大值，活性主要在色素层。根据生物分布数据计算了人体吸收辐射剂量。关键器官是眼睛（I-123 IMP 为 0.407 拉德/毫居里）。当含有 4%的 I-124 IMP 污染时，眼部剂量增加到 1.11 拉德/毫居里；当含有 0.4%的 I-125 IMP 污染时，眼部剂量增加到 0.535 拉德/毫居里。纯 I-123 IMP 时肝脏吸收剂量为 0.127 拉德/毫居里，甲状腺剂量为 0.120 拉德/毫居里，二者都会因 I-124 或 I-125 污染而增加。虽然尚未在人体中报道过延迟的眼部摄取情况，但应谨慎将 I-124 或 I-125 的污染量限制在实际可行的最低水平。
