Chleide E, Bruhwyler J, Mercier M
Department of Psychology, Faculty of Medicine, Namur University, Belgium.
Pharmacol Biochem Behav. 1991 Sep;40(1):1-6. doi: 10.1016/0091-3057(91)90312-p.
Rats were trained on a fixed-interval schedule of 60 s (FI 60). After stabilization of performance, rats were chronically submitted to hypoxic treatment (3.5% O2, 10 min) once a day, immediately after the daily FI 60 session. Hypoxia disturbed the retention of FI responding. It was mainly characterized by a decrease in response rate and in pause duration, and by changes in the temporal distribution of responses. Animals receiving piracetam (100 mg/kg, IP) 30 min before each FI session followed by hypoxia were significantly less affected than saline-treated animals. Results are discussed with reference to the effects of hypoxia and piracetam on nonspecific factors and on memory function. It is suggested that the effects of piracetam are due to alleviation of hypoxia-induced memory retrieval deficit rather than to a protection against hypoxic brain cell injury.
大鼠接受了60秒固定间隔（FI 60）的训练。在行为表现稳定后，大鼠每天在FI 60训练结束后立即接受一次慢性低氧处理（3.5%氧气，10分钟）。低氧干扰了FI反应的保持。其主要特征为反应率和停顿时间减少，以及反应的时间分布发生变化。在每次FI训练前30分钟腹腔注射吡拉西坦（100毫克/千克）然后接受低氧处理的动物，受影响程度明显低于接受生理盐水处理的动物。结合低氧和吡拉西坦对非特异性因素及记忆功能的影响对结果进行了讨论。有人提出，吡拉西坦的作用是由于减轻了低氧诱导的记忆提取缺陷，而非防止低氧性脑细胞损伤。
