Sara S J, David-Remacle M, Weyers M, Giurgea C
Psychopharmacology (Berl). 1979 Mar 14;61(1):71-5. doi: 10.1007/BF00426813.
Rats were trained on a continuously reinforced bar-press response for water reward. Seven days later they were retested for retention, with or without pretest injection of the nootropic drug, piracetam. Drug-treated animals had significantly shorter response latencies than saline-treated animals. The results are interpreted as a facilitation of retrieval processes after forgetting. The experiment was extended under extinction conditions and it was found that after three sessions there was a tendency to facilitate extinction when response latency is used as the extinction index. The clinical interest of a drug which facilitates the retrieval aspect of the memory process without impairing extinction is discussed.
大鼠接受连续强化的压杆反应训练以获取水奖励。七天后，对它们进行记忆保持测试，测试时有的注射促智药吡拉西坦，有的不注射。接受药物治疗的动物的反应潜伏期明显短于接受生理盐水治疗的动物。这些结果被解释为遗忘后检索过程得到促进。实验在消退条件下进行了扩展，发现当以反应潜伏期作为消退指标时，经过三个阶段后有促进消退的趋势。文中讨论了一种在不损害消退的情况下促进记忆过程检索方面的药物的临床意义。
