Sara S J
Psychopharmacology (Berl). 1980;68(3):235-41. doi: 10.1007/BF00428109.
Etiracetam, a nonanaleptic drug related to the nootropic substance piracetam, was found to facilitate memory retrieval in rats in several experimental situations, when injected 30 min prior to retention testing. The drug was active when memory deficits were induced by electroconvulsive shock, undertraining, or by a long training-to-test interval. The behavioral paradigms included a one-trial inhibitory avoidance task and a complex multitrial, spatially discriminated approach task. The clinical interest of drugs which facilitate retrieval processes is also discussed.
乙拉西坦是一种与促智药吡拉西坦相关的非麻醉性药物，发现在几种实验情况下，于记忆保持测试前30分钟注射时，它能促进大鼠的记忆恢复。当记忆缺陷由电惊厥休克、训练不足或长时间的训练至测试间隔诱导产生时，该药物具有活性。行为范式包括单次试验抑制性回避任务和复杂的多次试验、空间辨别接近任务。还讨论了促进恢复过程的药物的临床意义。
