Oben Julius, Enonchong Ebangha, Kuate Dieudonne, Mbanya Dora, Thomas Tiffany C, Hildreth DeWall J, Ingolia Thomas D, Tempesta Michael S
Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, BP 812, University of Yaoundé I, Yaoundé,Cameroon.
Lipids Health Dis. 2007 Sep 5;6:20. doi: 10.1186/1476-511X-6-20.
Metabolic Syndrome, or Syndrome X, is characterized by a set of metabolic and lipid imbalances that greatly increases the risk of developing diabetes and cardiovascular disease. The syndrome is highly prevalent in the United States and worldwide, and treatments are in high demand. ProAlgaZyme, a novel and proprietary freshwater algae infusion in purified water, has been the subject of several animal studies and has demonstrated low toxicity even with chronic administration at elevated doses. The infusion has been used historically for the treatment of several inflammatory and immune disorders in humans and is considered well-tolerated. Here, the infusion is evaluated for its effects on the cardiovascular risk factors present in metabolic syndrome in a randomized double-blind placebo-controlled study involving 60 overweight and obese persons, ages 25-60. All participants received four daily oral doses (1 fl oz) of ProAlgaZyme (N = 22) or water placebo (N = 30) for a total of 10 weeks, and were encouraged to maintain their normal levels of physical activity. Blood sampling and anthropometric measurements were taken at the beginning of the study period and after 4, 8 and 10 weeks of treatment. Eight participants did not complete the study.
ProAlgaZyme brought about statistically significant (p < 0.001) reductions in the following: weight, body fat, total cholesterol, LDL-cholesterol, triglycerides, C-reactive protein and fasting blood glucose levels, accompanied by a significant (p < 0.001) increase in HDL-cholesterol levels over the 10-week study period. The infusion was well-tolerated and no side effects were noted.
ProAlgaZyme (4 fl oz daily) consumption resulted in significant reductions in weight and blood glucose levels, while significantly improving serum lipid profiles and reducing markers of inflammation, thus improving cardiovascular risk factors in overweight and obese subjects over a course of 10 weeks with an absence of adverse side effects.
代谢综合征,又称X综合征,其特征是一系列代谢和脂质失衡,会大大增加患糖尿病和心血管疾病的风险。该综合征在美国和全球都非常普遍,对治疗的需求很高。ProAlgaZyme是一种新型的专利产品,为纯净水中注入淡水藻类提取物,已经进行了多项动物研究,并且即使在高剂量长期给药的情况下也显示出低毒性。该提取物在历史上一直用于治疗人类的多种炎症和免疫疾病,并且被认为耐受性良好。在此,在一项涉及60名年龄在25至60岁之间的超重和肥胖者的随机双盲安慰剂对照研究中,评估了该提取物对代谢综合征中存在的心血管危险因素的影响。所有参与者每天口服四剂(1液量盎司)ProAlgaZyme(N = 22)或水安慰剂(N = 30),共10周,并被鼓励保持正常的身体活动水平。在研究期开始时以及治疗4、8和10周后进行血液采样和人体测量。八名参与者未完成研究。
在为期10周的研究期内,ProAlgaZyme在以下方面带来了具有统计学意义(p < 0.001)的降低:体重、体脂、总胆固醇、低密度脂蛋白胆固醇、甘油三酯、C反应蛋白和空腹血糖水平,同时高密度脂蛋白胆固醇水平显著(p < 0.001)升高。该提取物耐受性良好,未观察到副作用。
每天服用ProAlgaZyme(4液量盎司)可显著降低体重和血糖水平,同时显著改善血脂谱并降低炎症标志物,从而在10周内改善超重和肥胖受试者的心血管危险因素,且无不良副作用。