Truong Daniel D, Bhidayasiri Roongroj, Wolters Erik
The Parkinson's and Movement Disorder Institute, 9940 Talbert Avenue, Fountain Valley, CA 92708, USA.
J Neurol Sci. 2008 Mar 15;266(1-2):216-28. doi: 10.1016/j.jns.2007.08.015. Epub 2007 Sep 4.
Progress in pharmacology has markedly improved the treatment of early Parkinson's disease. The management of advanced Parkinson's symptoms, however, remains a challenge. These symptoms are divided into motor and non-motor symptoms. Non-motor symptoms may appear early or late in the disease and sometimes even before the onset of the first motor symptoms confirming the diagnosis. The spectrum of non-motor symptoms encompasses autonomic dysfunctions, sleep disorders, mood disorders, impulse control disorders, cognitive dysfunction, dementia, paranoia and hallucinations. They are often less appreciated than motor symptoms but are important sources of disability for many PD patients. This review describes these non-motor symptoms and their managements.
药理学的进展显著改善了早期帕金森病的治疗。然而,晚期帕金森病症状的管理仍然是一项挑战。这些症状分为运动症状和非运动症状。非运动症状可能在疾病的早期或晚期出现,有时甚至在确诊的首个运动症状出现之前就已出现。非运动症状的范围包括自主神经功能障碍、睡眠障碍、情绪障碍、冲动控制障碍、认知功能障碍、痴呆、偏执和幻觉。它们往往不如运动症状受重视,但却是许多帕金森病患者致残的重要原因。这篇综述描述了这些非运动症状及其管理方法。