Prallet B, Alexandre C, Baron R
Laboratoire de Biologie du Tissu Osseux, Université de Médecine, Saint-Etienne.
Rev Rhum Mal Osteoartic. 1991 Nov 30;58(11):777-80.
Osteoclast is derived from mononuclear hematopoietic stem cells, most likely within the granulocyte-macrophage lineage. The exact differentiation process of osteoclasts precurssors has only been partially uncovered. The authors isolated in vitro, from the medullary bone of hens a mononuclear precursor of the osteoclast. This cell expressed several characteristics of mature and multinucleated osteoclast including the capacity to resorb the extracellular bone matrix.
破骨细胞源自单核造血干细胞，极有可能来自粒细胞-巨噬细胞谱系。破骨细胞前体的确切分化过程仅被部分揭示。作者在体外从母鸡的骨髓骨中分离出了破骨细胞的单核前体。这种细胞表现出成熟多核破骨细胞的几种特征，包括吸收细胞外骨基质的能力。
