Rothstein R D, Alavi A, Reynolds J C
Department of Medicine, University of Pennsylvania, Philadelphia 19104.
Dig Dis Sci. 1993 Aug;38(8):1518-24. doi: 10.1007/BF01308614.
Abnormalities in the gastric pacemaker potentials occur in patients with impaired gastric emptying. It is unclear if treatment effects the underlying rhythm or if normalization of dysrhythmias is important. We examined the effect of cisapride using surface electrogastrograms and radionuclide gastric emptying studies of patients with idiopathic and diabetic gastroparesis. Twelve of 14 patients had abnormal baseline electrogastrograms. After six months of cisapride, four patients had normalization of their electrical activity and six had improvement. Patients with idiopathic gastroparesis had an increase in gastric emptying at 120 min from 48.9 +/- 3.8% (baseline) to 70.9 +/- 6.0% (six months), P = 0.009. Patients with diabetes mellitus had a similar improvement. Patients who had normalization of the electrogastrogram had a greater gastric emptying rate than patients with continued dysrhythmias. Thus, dysrhythmias are important in the etiology for gastroparesis, but other factors need to be examined.
胃排空受损患者存在胃起搏器电位异常。目前尚不清楚治疗是否会影响潜在节律，或者心律失常的正常化是否重要。我们使用体表胃电图和放射性核素胃排空研究，对特发性和糖尿病性胃轻瘫患者进行西沙必利治疗效果的研究。14例患者中有12例基线胃电图异常。服用西沙必利6个月后，4例患者的电活动恢复正常，6例患者有所改善。特发性胃轻瘫患者在120分钟时的胃排空率从48.9±3.8%（基线）增加到70.9±6.0%（6个月），P = 0.009。糖尿病患者也有类似改善。胃电图恢复正常的患者比仍有心律失常的患者胃排空率更高。因此，心律失常在胃轻瘫的病因中很重要，但还需要研究其他因素。
