Snow R W, Byass P, Shenton F C, Greenwood B M
Medical Research Council Laboratories, Fajara, Banjul, The Gambia.
Trans R Soc Trop Med Hyg. 1991 Sep-Oct;85(5):584-9. doi: 10.1016/0035-9203(91)90351-x.
Anthropometric measurements were made and serum iron and ferritin levels determined in a group of Gambian children at the beginning of the rainy season and these findings were related to the malaria experience of the children during the following malaria transmission season. Susceptibility to malaria was not correlated with prior weight-for-age, height-for-age, weight-for-height or serum albumin, or with serum iron, serum iron binding capacity nor serum ferritin. Thus, our findings do not provide any support for the view that poor nutritional status, as assessed by anthropometric measurements, or iron deficiency protect against malaria infection. Children who developed a clinical attack of malaria accompanied by a high level of parasitaemia tended to have a higher mean weight-for-age at the beginning of the rainy season than did children who had a clinical attack accompanied by a low level of parasitaemia, but the difference between groups was not statistically significant. However, they had a significantly higher mean serum ferritin level (P less than 0.01).
在雨季开始时，对一组冈比亚儿童进行了人体测量，并测定了血清铁和铁蛋白水平，这些结果与儿童在随后疟疾传播季节的疟疾感染经历相关。对疟疾的易感性与先前的年龄别体重、年龄别身高、身高别体重或血清白蛋白无关，也与血清铁、血清铁结合能力和血清铁蛋白无关。因此，我们的研究结果不支持以下观点：通过人体测量评估的营养不良或缺铁可预防疟疾感染。出现伴有高寄生虫血症的疟疾临床发作的儿童在雨季开始时的平均年龄别体重往往高于伴有低寄生虫血症临床发作的儿童，但两组之间的差异无统计学意义。然而，他们的平均血清铁蛋白水平显著更高（P小于0.01）。
