Jansen J F, de Brabander-van den Berg E M, Meijer E W
Science. 1994 Nov 18;266(5188):1226-9. doi: 10.1126/science.266.5188.1226.
Dendrimers are well-defined, highly branched macromolecules that emanate from a central core and are synthesized through a stepwise, repetitive reaction sequence. The synthesis and characterization of dendritic boxes, based on the construction of a chiral shell of protected amino acids onto poly(propyleneimine) dendrimers with 64 amine end groups, is reported here. Nuclear magnetic resonance-relaxation and optical data show that a dense shell with solid-phase character is formed. Guest molecules were captured within the internal cavities of the boxes when these boxes were constructed in the presence of guest molecules. The diffusion of guest molecules out of the boxes into solution was unmeasurably slow because of the close packing of the shell. These monomolecular dendritic containers of 5-nanometer dimensions with physically locked-in guest molecules were characterized spectroscopically.
树枝状聚合物是定义明确、高度分支的大分子，从中心核向外延伸，并通过逐步重复的反应序列合成。本文报道了基于在具有64个胺端基的聚（丙烯亚胺）树枝状聚合物上构建受保护氨基酸的手性壳层来合成和表征树枝状盒。核磁共振弛豫和光学数据表明形成了具有固相特征的致密壳层。当在客体分子存在的情况下构建这些盒时，客体分子被捕获在盒的内部空腔中。由于壳层的紧密堆积，客体分子从盒中扩散到溶液中的速度极慢，几乎无法测量。这些尺寸为5纳米、物理上锁定有客体分子的单分子树枝状容器通过光谱进行了表征。
