Kniazev P G, Kuznetsov O K, Perevozchikov A P, Korobitsyn L P, Zhudina A I
Vopr Onkol. 1976;22(1):47-53.
The infection process was reproduced in the culture of chick embryonal cells by means of: a) DNA isolated from chick Rous sarcoma (Carr-Zilber strain); b) DNA from blood cells of chicks with myeloblastosis (strain A); c) DNA from Rous virus malignified (Prague strain) rat cells (XC). Antigenic properties of the virus, transfected with DNA from chick Rous sarcoma, would differ from the original parental strain (Carr-Zilber RSV), that evidences the possibility of a partial transfer of genetic information in transfection. A suggestion is made on four presumable variants of oncornaviruses transfection by means of tumor cells DNA.
a）从鸡劳氏肉瘤（卡尔-齐尔伯株）中分离的DNA；b）来自患有成髓细胞增多症的鸡（A株）血细胞的DNA；c）来自劳氏病毒恶性转化（布拉格株）大鼠细胞（XC）的DNA。用来自鸡劳氏肉瘤的DNA转染的病毒的抗原特性将不同于原始亲本株（卡尔-齐尔伯劳氏肉瘤病毒），这证明了在转染过程中遗传信息部分转移的可能性。提出了关于通过肿瘤细胞DNA转染肿瘤病毒的四种可能变体的建议。
