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[通过肿瘤细胞DNA转移致癌RNA病毒的遗传信息]

[Transfer of the genetic information of oncornaviruses by means of tumor cell DNA].

作者信息

Kniazev P G, Kuznetsov O K, Perevozchikov A P, Korobitsyn L P, Zhudina A I

出版信息

Vopr Onkol. 1976;22(1):47-53.

PMID:178103
Abstract

The infection process was reproduced in the culture of chick embryonal cells by means of: a) DNA isolated from chick Rous sarcoma (Carr-Zilber strain); b) DNA from blood cells of chicks with myeloblastosis (strain A); c) DNA from Rous virus malignified (Prague strain) rat cells (XC). Antigenic properties of the virus, transfected with DNA from chick Rous sarcoma, would differ from the original parental strain (Carr-Zilber RSV), that evidences the possibility of a partial transfer of genetic information in transfection. A suggestion is made on four presumable variants of oncornaviruses transfection by means of tumor cells DNA.

摘要

通过以下方式在鸡胚细胞培养物中重现了感染过程

a)从鸡劳氏肉瘤(卡尔-齐尔伯株)中分离的DNA;b)来自患有成髓细胞增多症的鸡(A株)血细胞的DNA;c)来自劳氏病毒恶性转化(布拉格株)大鼠细胞(XC)的DNA。用来自鸡劳氏肉瘤的DNA转染的病毒的抗原特性将不同于原始亲本株(卡尔-齐尔伯劳氏肉瘤病毒),这证明了在转染过程中遗传信息部分转移的可能性。提出了关于通过肿瘤细胞DNA转染肿瘤病毒的四种可能变体的建议。

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