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[食管癌腔内照射]

[Intracavitary irradiation of esophageal cancer].

作者信息

Keldsen N, Bentzen J, Knudsen J B, Hansen H S

机构信息

Onkologisk afdeling, Finseninstituet, Rigshospitalet, København.

出版信息

Ugeskr Laeger. 1991 Aug 12;153(33):2295-8.

PMID:1781050
Abstract

Intracavitary irradiation (ICI) of esophageal cancer is a technique where the radioactive source is placed in the lumen of the esophagus thereby delivering a high local radiation dose to the tumor. ICI is used as single modality therapy for palliation of dysphagia or as a supplement to external irradiation. Dysphagia is hereby relieved in more than 90% of the patients and it appears that survival is improved. The side effects are dose dependent and consist of esophagitis, esophageal ulceration and benign stricture. Fistulae do not seem to occur with increased frequency after ICI, but an existing fistula is claimed to be a contraindication to ICI. The mortality connected with ICI is considerably lower than with tubulation or laser extirpation. It is concluded that ICI is a promising treatment in esophageal cancer both as palliative and curative treatment in combination with other treatment modalities.

摘要

食管癌腔内照射(ICI)是一种将放射源置于食管腔内,从而对肿瘤给予高局部辐射剂量的技术。ICI用作缓解吞咽困难的单一治疗方式或作为外照射的补充。据此,超过90%的患者吞咽困难得到缓解,且似乎生存期有所改善。副作用与剂量相关,包括食管炎、食管溃疡和良性狭窄。ICI后瘘管似乎不会更频繁地发生,但已有瘘管被认为是ICI的禁忌证。与ICI相关的死亡率远低于置管或激光切除。结论是,ICI作为与其他治疗方式联合的姑息性和根治性治疗,在食管癌治疗中是一种有前景的治疗方法。

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