Marakos P, Foscolos G B, Fytas G, Kolocouris N, Vamvakidès A
Laboratoire de Chimie Pharmaceutique, Université d'Athènes, Grèce.
Ann Pharm Fr. 1991;49(4):214-21.
The alpha-phenyl-1-adamantanemethanamine 2 was synthesized and its pharmacological action was studied on mice. The behavior effects obtained with this compound (at low dose) as well as the antagonism of the convulsions and the lethality (induced by the amine 2 at high dose) by desimipramine, N-linoleylGABA or N-linoleylglycine, could suggest the existence of glutamatergic (NMDA), anti-GABAergic and antiglycinergic components in the action mechanism of this adamantanamine.
合成了α-苯基-1-金刚烷甲胺2，并对其在小鼠身上的药理作用进行了研究。该化合物（低剂量时）产生的行为效应，以及地昔帕明、N-亚油酰基GABA或N-亚油酰基甘氨酸对其（高剂量时）引起的惊厥和致死性的拮抗作用，可能提示该金刚烷胺作用机制中存在谷氨酸能（NMDA）、抗GABA能和抗甘氨酸能成分。
