Montalescot G
Service de Cardiologie, Hôpital Pitié-Salpêtrière, Paris.
Ann Cardiol Angeiol (Paris). 1991 Dec;40(10):603-6.
More and more heparins are available to the prescriber and low molecular weight heparins have brought about a modification of prescribing habits. Some complications linked to the use of heparins remain insufficiently known: thrombocytopenia and acute pulmonary hypertension during neutralization for example. Treatment monitoring must be clearly codified to increase effectiveness and reduce the number of accidents thus achieving a better risk/benefit ratio for such treatment. Some of the Vitamin K antagonists have specific properties which should be known, particularly relating to their half-life. Monitoring is important, it is provided by INR and adapted to the indications. The world of anticoagulants is in flux; the movement must be followed as it may well accelerate with the arrival of new antithrombotic drugs.
可供开处方者选择的肝素越来越多，低分子量肝素已经改变了处方习惯。一些与肝素使用相关的并发症仍未得到充分了解：例如，中和过程中的血小板减少症和急性肺动脉高压。必须明确规范治疗监测，以提高疗效并减少事故数量，从而实现此类治疗更好的风险/效益比。一些维生素K拮抗剂具有应为人所知的特殊性质，尤其是与它们的半衰期有关的性质。监测很重要，通过国际标准化比值（INR）进行监测并根据适应证进行调整。抗凝药物领域正在不断变化；必须紧跟这一动态，因为随着新的抗血栓药物的出现，这一变化可能会加速。
