Keenan M J, Hegsted M, Siver F, Mohan R, Wozniak P
Human Nutrition and Food, School of Human Ecology, Louisiana State University Agricultural Center, Baton Rouge.
Ann Nutr Metab. 1991;35(6):315-27. doi: 10.1159/000177664.
Two separate studies were conducted using weanling rats from either an unsupplemented, low vitamin D colony or a supplemented, adequate vitamin D colony. Severe hypocalcemia, slower increases in body weight gain, and lower apparent calcium, magnesium, and phosphorus balance values occurred in the rats from the low vitamin D colony fed a purified AIN-76A, vitamin D-devoid diet compared to rats from the vitamin D-adequate colony fed the same diet. Apparent calcium, magnesium, and phosphorus balance values, as well as most other measurements, in rats from the low vitamin D colony fed a purified AIN-76a, vitamin D-adequate diet were greater than or equal to those of rats never subjected to low vitamin D. This was suggestive of overcompensation in recovery from low maternal vitamin D. However, rats from the low vitamin D colony fed an unrefined (chow), vitamin D-adequate diet had lower apparent balance and bone values compared with rats from the vitamin D-supplemented colony fed the same diet. Presumably high levels of calcium, magnesium, and phosphorous in the unrefined diet prevented any overcompensation during recovery, as occurred with purified diets, from the earlier vitamin D deficiency. Overall, results indicated weanling rats from a low vitamin D colony had low vitamin D stores and were marginally vitamin D-deficient. In addition, recovery from the marginal deficiency had occurred to a large extent after feeding a purified, vitamin D-adequate diet. The results suggest the use of low vitamin D colony rats as a model for human, marginal vitamin D deficiency.
使用来自未补充维生素D的低维生素D群体或补充了充足维生素D群体的断乳大鼠进行了两项独立研究。与喂食相同纯化AIN-76A、缺乏维生素D饮食的充足维生素D群体的大鼠相比，来自低维生素D群体的大鼠喂食纯化AIN-76A、缺乏维生素D饮食时出现严重低钙血症、体重增加增速较慢以及表观钙、镁和磷平衡值较低。来自低维生素D群体的大鼠喂食纯化AIN-76a、维生素D充足饮食时的表观钙、镁和磷平衡值以及大多数其他测量值大于或等于从未经历过低维生素D的大鼠。这表明从母体低维生素D状态恢复时存在过度补偿。然而，与喂食相同饮食的补充维生素D群体的大鼠相比，来自低维生素D群体的大鼠喂食未精制（饲料）、维生素D充足饮食时的表观平衡和骨骼值较低。据推测，未精制饮食中高水平的钙、镁和磷阻止了从早期维生素D缺乏状态恢复时像纯化饮食那样出现的任何过度补偿。总体而言，结果表明来自低维生素D群体的断乳大鼠维生素D储备较低且处于边缘性维生素D缺乏状态。此外，在喂食纯化、维生素D充足饮食后，很大程度上已从边缘性缺乏状态恢复。结果提示可将低维生素D群体大鼠用作人类边缘性维生素D缺乏的模型。
