Romanenko I M, Araviĭskiĭ R A
Antibiot Khimioter. 1991 Sep;36(9):29-31.
A comparative study of the amphotericin B contents in the skin and subcutaneous fatty tissue was performed on guinea pigs after local application of amphotericin ointment by phonophoresis and with preliminary treatment of the skin by dimethyl sulfoxide (DMSO). When the amphotericin ointment was used in combination with ultrasound the content of amphotericin B in the skin and subcutaneous fatty tissue 1, 3, 24, 48 and 72 hours after the application was much higher than that after the ointment local application without the ultrasonic treatment. When the amphotericin ointment was applied locally after the preliminary treatment with DMSO the maximum content of the antibiotic in the skin and subcutaneous fatty tissue was observed 3 hours after the application which was significantly higher than the content observed after the ointment application by phonophoresis and especially locally without the ultrasonic treatment. In 24, 48 and 72 hours the amphotericin B concentration in the skin and subcutaneous fatty tissue under any conditions lowered and in 24 hours had a tendency to level in the areas treated with ultrasound and DMSO. In 48 and 72 hours the highest concentrations of the antibiotic were in the skin and subcutaneous fatty tissue after the ointment application by phonophoresis.
通过超声导入法局部应用两性霉素软膏，并在皮肤用二甲亚砜（DMSO）预处理后，对豚鼠皮肤和皮下脂肪组织中的两性霉素B含量进行了比较研究。当两性霉素软膏与超声联合使用时，给药后1、3、24、48和72小时皮肤和皮下脂肪组织中两性霉素B的含量远高于未进行超声处理而局部应用软膏后的含量。当两性霉素软膏在经DMSO预处理后局部应用时，给药后3小时观察到皮肤和皮下脂肪组织中抗生素的最大含量，该含量显著高于经超声导入法应用软膏后，尤其是未进行超声处理而局部应用时所观察到的含量。在24、48和72小时，任何条件下皮肤和皮下脂肪组织中两性霉素B的浓度均降低，且在24小时时，经超声和DMSO处理的区域有趋于平稳的趋势。在48和72小时时，经超声导入法应用软膏后，皮肤和皮下脂肪组织中抗生素的浓度最高。
