Nesković N K, Karan V Z, Vitorović S L, Vojinović V D
INEP, Institute of Pesticides and Environmental Protection, Banatska, Belgrade-Zemun, Yugoslavia.
Biomed Environ Sci. 1991 Dec;4(4):423-32.
The level of bound malathion residues in treated wheat grain and its toxic effects on rats were investigated. Wheat grain was treated with [14C] malathion (specific activity: 2.76 MBq/mg) to determine the bioavailability of bound residues in rats. At the same time, grain was treated with nonlabeled malathion to test for possible toxic effects of bound residues in a subchronic (90 days) feeding study in rats at two dose levels, 10 and 100 ppm. It was observed that the level of malathion-bound residues amounted to 11.28% of the applied dose (for six months). Also, it was noted that the main route of [14C]-malathion excretion was through the urine. This signifies that grain-bound malathion was bioavailable. In subchronic test on rats bound malathion residues (both dose levels) induced effects to some extent in organ weight (spleen and adrenals), and blood ChE activity. In both, males and females, there was an increase in SGPT activity (lower dose), and in alkaline phosphatase in females (higher dose). Hematological data showed changes only in hemoglobin concentration in males (both dose levels).
研究了处理过的小麦籽粒中马拉硫磷结合残留水平及其对大鼠的毒性作用。用[14C]马拉硫磷（比活度：2.76 MBq/mg）处理小麦籽粒，以确定大鼠体内结合残留的生物利用度。同时，用未标记的马拉硫磷处理籽粒，在大鼠的一项为期90天的亚慢性喂养研究中，以10 ppm和100 ppm两个剂量水平测试结合残留的可能毒性作用。观察到马拉硫磷结合残留水平占施用量的11.28%（六个月）。此外，还注意到[14C]马拉硫磷的主要排泄途径是通过尿液。这表明籽粒结合的马拉硫磷具有生物利用度。在对大鼠的亚慢性试验中，结合的马拉硫磷残留（两个剂量水平）在一定程度上对器官重量（脾脏和肾上腺）和血液胆碱酯酶活性产生了影响。在雄性和雌性大鼠中，谷丙转氨酶活性均有升高（低剂量组），雌性大鼠碱性磷酸酶活性升高（高剂量组）。血液学数据仅显示雄性大鼠血红蛋白浓度有变化（两个剂量水平）。
