Aaron J E, de Vernejoul M C, Kanis J A
Department of Human Metabolism and Clinical Biochemistry, University of Sheffield, England.
Bone. 1991;12(5):307-10. doi: 10.1016/8756-3282(91)90015-b.
The effect of sodium fluoride therapy on iliac trabecular bone has been studied in 15 patients with primary osteoporosis by comparing bone biopsies taken before and after two years of treatment. A marked increase in bone volume (43%) was observed, which was attributable to an increase in trabecular thickness (46%) rather than their number. Because the trabecular bone surface, the trabecular number, the bone volume/trabecular width ratio, and the trabecular terminus number do not change significantly after fluoride treatment, we conclude that fluoride does not induce the de novo generation of trabeculae, nor does it restore trabecular connectivity despite the restoration of bone mass. These data suggest that the restoration of skeletal mass with fluoride may not lead to a comparable decrease in the risk of future fracture.
通过比较15例原发性骨质疏松症患者在两年氟化钠治疗前后的骨活检情况，研究了氟化钠治疗对髂骨小梁骨的影响。观察到骨体积显著增加（43%），这归因于小梁厚度增加（46%）而非小梁数量增加。由于氟化钠治疗后小梁骨表面、小梁数量、骨体积/小梁宽度比及小梁末端数量均无显著变化，我们得出结论：氟化钠不会诱导小梁的新生，也不会恢复小梁连接性，尽管骨量有所恢复。这些数据表明，用氟化钠恢复骨骼质量可能不会导致未来骨折风险出现类似程度的降低。
