Ohata M, Irako M
Second Department of Surgery, Nihon University School of Medicine, Tokyo, Japan.
Hum Cell. 1991 Sep;4(3):204-11.
It is very important to clarify the mechanism of the regeneration of the respiratory epithelium in not only Oto-Naso-Laryngology but also in the field of chest medicine and surgery. Because of the experimental study carried out on dogs, involving the curing process of the tracheal anastomosis site, a scanning electron microscopic study showed that after two weeks, ciliated cells could be seen making a thin layer. It took nine weeks or more till the whole tracheal anastomosis site was completely covered by the ciliated epithelial cells. Having reviewed the experimental papers concerning the regeneration of the respiratory epithelium which have been published since 1953, a conclusion has been reached that after the injury of the respiratory mucosa, the existence of the basement membranes remains were covered by the migration of the traditional epithelium from the margin of the wound and four weeks later, the wound was covered by the normal epithelium. It has been stated up until now that the differentiation of the epithelium was covered from basement cells, but in fact, it seems to occur from the secretory cells. This has been demonstrated by the culture process of the respiratory epithelium. From these facts, the cultured respiratory epithelium cells are very important in elucidating carcinogenesis.
阐明呼吸上皮再生机制不仅在耳鼻咽喉科，而且在胸科医学与外科领域都非常重要。由于对狗进行了涉及气管吻合部位愈合过程的实验研究，扫描电子显微镜研究显示，两周后可见纤毛细胞形成薄层。整个气管吻合部位完全被纤毛上皮细胞覆盖需要九周或更长时间。回顾自1953年以来发表的有关呼吸上皮再生的实验论文后得出结论，呼吸黏膜损伤后，基底膜仍然存在，传统上皮从伤口边缘迁移将其覆盖，四周后伤口被正常上皮覆盖。到目前为止一直认为上皮分化是由基底细胞完成的，但实际上似乎是由分泌细胞完成的。这已通过呼吸上皮的培养过程得到证实。基于这些事实，培养的呼吸上皮细胞在阐明致癌机制方面非常重要。
