Lundgren R, Hörstedt P, Winblad B
Eur J Respir Dis. 1983 Jan;64(1):9-23.
Bronchial brushing is one of the main methods of obtaining bronchial mucosal material for cytologic examination. In 37 rabbits, the tracheal respiratory mucosa, brush biopsy damage and post-biopsy wound-healing were studied. In the majority of animals, the brush had penetrated the basement membrane but in animals with undamaged basement membrane there was, within one to two days, a covering cell layer, probably regenerated from the intact epithelium and from basal cells. Deep, wound areas were covered during the first two to three days after damage by granulation tissue protruding into the tracheal lumen. After rejection of the granulation tissue, ulceration was covered by epithelium within three days and a normal ciliated epithelium restored within three weeks.
支气管刷检是获取支气管黏膜材料进行细胞学检查的主要方法之一。对37只兔子的气管呼吸黏膜、刷检活检损伤及活检后伤口愈合情况进行了研究。在大多数动物中，刷子已穿透基底膜，但在基底膜未受损的动物中，在1至2天内有一层覆盖细胞层，可能是由完整上皮和基底细胞再生而来。损伤后的头两到三天，深部伤口区域被突入气管腔的肉芽组织覆盖。肉芽组织被清除后，溃疡在三天内被上皮覆盖，三周内恢复正常的纤毛上皮。
