Majima T, Irie T, Sawaguchi N, Funakoshi T, Iwasaki N, Harada K, Minami A, Nishimura S-I
Department of Orthopaedic Surgery, Hokkaido University School of Medicine, Sapporo, 060-8638, Japan.
Proc Inst Mech Eng H. 2007 Jul;221(5):537-46. doi: 10.1243/09544119JEIM203.
To establish medical use of tissue engineering technology for ligament and tendon injuries, a scaffold was developed which has sufficient ability for cell growth, cell differentiation, and mechanical properties. The scaffold made from chitosan and 0.1 per cent hyaluronic acid has adequate biodegradability and biocompatibility. An animal experiment showed that the scaffold has less toxicity and less inflammation induction. Furthermore, in-vivo animal experiments showed that the mechanical properties of the engineered ligament or tendon had the possibility to stabilize the joint. It was shown that newly developed hybrid-polymer fibre scaffold has feasibility for joint tissue engineering.
为确立组织工程技术在韧带和肌腱损伤治疗中的医学应用，研发了一种具有足够细胞生长、细胞分化能力及机械性能的支架。由壳聚糖和0.1%透明质酸制成的该支架具有足够的生物降解性和生物相容性。动物实验表明该支架毒性较小且诱导炎症的能力较弱。此外，体内动物实验表明，工程化韧带或肌腱的机械性能有可能稳定关节。结果表明，新开发的混合聚合物纤维支架在关节组织工程方面具有可行性。
