Mzareulov K D
Biokhimiia. 1991 Aug;56(8):1385-96.
Based on the results of a semi-empirical analysis, several structural types of human and sea whale somatotropins and placental lactogen lipotropic actons which correspond, apparently, to the biologically active conformation common for the given molecular family, were identified. Chemical modification of human somatotropin lipotropic acton whose conformational possibilities selectively model the most preferential structure of the natural oligopeptide are proposed.
基于半经验分析结果，确定了几种人类和海鲸生长激素以及胎盘催乳素促脂活性的结构类型，这些结构类型显然与给定分子家族共有的生物活性构象相对应。提出了对人类生长激素促脂活性进行化学修饰的方法，其构象可能性选择性地模拟了天然寡肽的最优先结构。
